·      Ibogaine certainly affects the heart and the cardiovascular system. Besides lowering the heart rate, therapeutic concentrations of the alkaloid interact with cardiac ion channels, and these effects most likely determine ibogaine’s potentially life-threatening cardiotoxicity. Due to the longevity of noribogaine—ibogaine’s active metabolite—in human plasma, cardiac adverse events may also occur several days, in some cases weeks after intake of a single dose of ibogaine.
·      Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382526/